Skip to content
MediCaine MEDICAINE
LICENSED 503A COMPOUNDING

COMPOUNDING PHARMACY NUMBING CREAM

Professional-grade compound topical anesthetic formulations. BLT, LT, and quad-agent BLTP creams compounded fresh per order under USP 795 standards. Built for providers who demand more than off-the-shelf numbing.

503A COMPOUNDING

WHAT IS COMPOUNDED NUMBING CREAM?

Compounded numbing cream is a topical anesthetic preparation made by a licensed 503A compounding pharmacy according to a specific formulation. Unlike mass-manufactured products that come in fixed concentrations, compounded creams are prepared in small batches under strict pharmaceutical controls, allowing for customized agent combinations and concentrations that commercial products cannot offer.

Under Section 503A of the Federal Food, Drug, and Cosmetic Act, compounding pharmacies are authorized to prepare customized medications that are not commercially available or when a commercially available product does not meet a patient's clinical needs. This is the legal and regulatory framework that enables multi-agent numbing formulations like BLT cream, which combines three or four anesthetic agents in a single preparation.

The distinction matters for providers. Commercial topical anesthetics are limited to FDA-approved fixed formulations, typically containing a single active ingredient at a standardized concentration. Compounding removes those constraints, enabling higher concentrations, multi-agent synergy, and purpose-built formulations for specific procedure types.

MediCaine compounding pharmacy
FORMULATIONS

THREE COMPOUND FORMULATIONS

Each MediCaine formulation is a distinct compound topical anesthetic engineered for specific clinical requirements. Every batch is compounded fresh per order at a licensed 503A pharmacy.

BLT

BLT 20/10/10 -- MediCaine Pro

The triple-agent BLT compound combines Benzocaine 20%, Lidocaine 10%, and Tetracaine 10% with Phenylephrine 0.5% as a vasoconstrictor. This is the most widely requested compounding pharmacy numbing cream formulation in aesthetic and dermatological practice. Benzocaine provides rapid surface-level sodium channel blockade, Lidocaine delivers deep-tissue penetration with extended duration, and Tetracaine extends the overall numbing window with its long half-life. The vasoconstrictor keeps all three agents concentrated at the treatment site while reducing procedural bleeding.

Onset: ~15 min Duration: 2-4 hrs Triple-Agent
View MediCaine Pro →
LT

LT 30/7 -- MediCaine Elite

The high-concentration dual-agent formulation pairs Lidocaine 30% with Tetracaine 7%. This compound topical anesthetic is designed for providers who need maximum Lidocaine penetration without Benzocaine. The 30% Lidocaine concentration is significantly higher than any commercially available product and delivers exceptional deep-tissue anesthesia. Tetracaine at 7% provides the duration extension. This formulation is particularly suited for procedures where Benzocaine sensitivity is a concern or where pure amide-ester depth is preferred over surface-level speed.

Onset: ~20 min Duration: 1-3 hrs High-Concentration
View MediCaine Elite →
BLTP

BLTP QUAD-AGENT -- MediCaine Ultra

The maximum-potency compound topical anesthetic. Benzocaine 20%, Lidocaine 10%, Tetracaine 10%, and Prilocaine 8%, with Phenylephrine 0.5%. This quad-agent formulation adds a fourth anesthetic pathway that single-, dual-, and even triple-agent compounds cannot match. Prilocaine is an amide anesthetic that works synergistically with the BLT base, amplifying blockade across all tissue depths. The result is the most comprehensive nerve signal interruption available in a topical anesthetic cream. Compounded exclusively by MediCaine for providers performing high-intensity or extended-duration procedures.

Onset: ~15 min Duration: 3-5 hrs Quad-Agent Maximum
View MediCaine Ultra →
COMPOUNDED VS COMMERCIAL

WHY PROVIDERS CHOOSE COMPOUNDED

COMPOUNDED (MEDICAINE)
Multi-agent formulations (up to 4 anesthetics working synergistically)
Concentrations up to 30% Lidocaine -- far exceeding commercial limits
Vasoconstrictor included (Phenylephrine) for reduced bleeding and localized effect
Compounded fresh per order for maximum potency
Onset as fast as 15 minutes, duration up to 5 hours
Wholesale pricing with bulk and auto-reorder options
COMMERCIAL (EMLA, PLIAGLIS, ETC.)
Single or dual-agent only (EMLA: Lidocaine 2.5% + Prilocaine 2.5%)
Fixed low concentrations -- cannot be customized
No vasoconstrictor component
Mass-manufactured with long warehouse shelf time
Onset 30-60 minutes, duration 1-2 hours
Premium brand pricing with no volume discounts

Providers across dermatology, aesthetics, tattoo, permanent makeup, and pain management have increasingly moved away from commercial topical anesthetics like EMLA (Lidocaine 2.5% / Prilocaine 2.5%), Pliaglis (Lidocaine 7% / Tetracaine 7%), and Cetacaine spray. The reasons are consistent: commercial products use low concentrations that require extended application times and still underperform during painful procedures. A BLT cream from a compounding pharmacy delivers meaningfully higher anesthetic concentrations through multiple pathways, resulting in faster onset, deeper numbing, and significantly longer duration. For high-volume practices, the cost-per-procedure advantage of compound numbing cream wholesale ordering further accelerates the shift.

QUALITY ASSURANCE

USP 795/800 COMPLIANT

Every MediCaine formulation is compounded under strict pharmaceutical standards at a licensed facility in the United States.

USP 795/800 STANDARDS

All MediCaine products are compounded in compliance with United States Pharmacopeia chapters 795 (non-sterile compounding) and 800 (hazardous drug handling). This covers ingredient sourcing, preparation environment, beyond-use dating, and quality verification testing.

MADE IN USA

MediCaine is compounded exclusively at a licensed pharmacy facility in the United States. All active pharmaceutical ingredients are sourced from FDA-registered suppliers with full certificates of analysis. No offshore manufacturing, no gray-market ingredients.

FRESH PER ORDER

Every batch is compounded after your order is placed, not pulled from warehouse inventory. Fresh compounding ensures maximum active ingredient potency and extends effective shelf life from the day you receive it. Beyond-use dates are assigned per USP guidelines based on formulation stability data.

WHOLESALE ORDERING

BULK COMPOUND NUMBING CREAM

MediCaine serves high-volume practices with wholesale compound numbing cream in both jars and single-use packets. Whether you perform 10 procedures a week or 100, ordering is structured to reduce your per-unit cost and eliminate supply gaps.

Single-use packets provide precise dosing, reduce cross-contamination risk, and simplify compliance. Jars are available for practices that prefer traditional dispensing. All packaging options are available across all three formulation tiers.

Jars: 30g and 60g sizes in cream or ointment base
Single-use packets: Pre-measured for consistent application per procedure
Auto-reorder: Set your reorder schedule and never run out mid-week
Volume pricing: Cost per unit decreases with quantity -- ideal for multi-provider practices

PACKAGING OPTIONS

SINGLE-USE PACKETS

Pre-measured dosing. No cross-contamination. Ideal for high-volume clinics, mobile providers, and multi-room practices.

30G JARS

Standard provider jar. Airless pump option available for zero-waste dispensing and consistent dosing.

60G JARS

High-volume jar for busy practices. Best per-gram value. Available in cream or ointment base.

ORDERING

HOW TO ORDER

Three ways to place your compound numbing cream order. All orders require NPI verification for provider licensing compliance.

1

ONLINE CONFIGURATOR

Use the product configurator to select your formulation tier, base type (cream or ointment), packaging format, and quantity. The configurator shows live pricing and allows you to enable auto-reorder scheduling. Submit your order with NPI number for instant verification.

Open Configurator →
2

PHONE ORDER

Call our team directly to place an order, ask questions about formulations, or discuss bulk pricing for your practice. Our staff can walk you through tier selection, recommend packaging based on your procedure volume, and set up recurring orders.

Call (310) 889-0733 →
3

EMAIL

Send your order details, questions, or bulk pricing requests to our team. Include your NPI number, desired formulation, quantity, and preferred packaging. We respond to all provider inquiries within one business day.

hello@medicainenumb.com →

NPI VERIFICATION PROCESS

MediCaine compound numbing cream is available exclusively to licensed providers. During checkout, you will be asked to provide your National Provider Identifier (NPI) number. Our system verifies your NPI against the NPPES registry in real time to confirm your active provider license. This process takes seconds and is required for all first-time orders. Returning customers with a verified NPI on file can reorder without re-verification.

FAQ

COMPOUNDING PHARMACY FAQ

What is a 503A compounding pharmacy?+
A 503A compounding pharmacy is a licensed pharmacy authorized under Section 503A of the Federal Food, Drug, and Cosmetic Act to prepare customized medications per individual prescription. Unlike mass manufacturers, 503A pharmacies compound medications in small batches under strict pharmaceutical controls, allowing for customized agent combinations and concentrations not available in commercial products. MediCaine is compounded at a licensed 503A facility in the United States under USP 795 and 800 standards.
Why is compounded numbing cream better than commercial products?+
Compounded numbing cream offers three critical advantages over commercial products like EMLA or Pliaglis. First, higher concentrations -- up to 30% Lidocaine compared to EMLA's 2.5%. Second, multi-agent formulations that combine up to four anesthetic agents working through different sodium channel mechanisms for deeper, faster, and longer-lasting numbing. Third, customization -- compounded formulations can include vasoconstrictors like Phenylephrine to reduce bleeding and keep anesthetic agents concentrated at the treatment site. The result is onset as fast as 15 minutes and duration up to 5 hours, compared to 30-60 minute onset and 1-2 hour duration for commercial alternatives.
What is BLT cream?+
BLT cream is a compound topical anesthetic containing Benzocaine, Lidocaine, and Tetracaine. The standard BLT formulation used in MediCaine Pro is Benzocaine 20%, Lidocaine 10%, and Tetracaine 10%, with Phenylephrine 0.5% as a vasoconstrictor. Each agent targets different sodium channel subtypes: Benzocaine provides rapid surface-level blockade, Lidocaine delivers deep-tissue penetration, and Tetracaine extends the overall duration with its long half-life. BLT cream is the most widely requested compounding pharmacy numbing formulation in aesthetic and dermatological practice.
How do I order from a compounding pharmacy?+
Ordering MediCaine compound numbing cream can be done three ways: (1) Use the online product configurator to select your formulation tier, base type, packaging format, and quantity, then submit with your NPI number for instant verification. (2) Call (310) 889-0733 to speak with our team and place an order by phone. (3) Email hello@medicainenumb.com with your order details and NPI number. All orders require NPI verification to confirm active provider licensing. Products ship nationwide from our US-based compounding facility.
Is compound numbing cream FDA approved?+
Compound numbing cream is not individually FDA approved in the same way that mass-manufactured drugs are. Under Section 503A of the Federal Food, Drug, and Cosmetic Act, compounding pharmacies are exempt from FDA new drug approval requirements when preparing customized medications per prescription that are not commercially available or when commercial products do not meet clinical needs. However, all MediCaine products are compounded under USP 795 (non-sterile compounding) and USP 800 (hazardous drug handling) standards, using active pharmaceutical ingredients sourced exclusively from FDA-registered suppliers with full certificates of analysis.

READY TO ORDER COMPOUND NUMBING CREAM?

Professional-grade topical anesthetic compounded fresh per order in the USA. BLT, LT, and quad-agent BLTP formulations available in jars and single-use packets.